97 research outputs found
Simulations of MHD Instabilities in Intracluster Medium Including Anisotropic Thermal Conduction
We perform a suite of simulations of cooling cores in clusters of galaxies in
order to investigate the effect of the recently discovered heat flux buoyancy
instability (HBI) on the evolution of cores. Our models follow the
3-dimensional magnetohydrodynamics (MHD) of cooling cluster cores and capture
the effects of anisotropic heat conduction along the lines of magnetic field,
but do not account for the cosmological setting of clusters or the presence of
AGN. Our model clusters can be divided into three groups according to their
final thermodynamical state: catastrophically collapsing cores, isothermal
cores, and an intermediate group whose final state is determined by the initial
configuration of magnetic field. Modeled cores that are reminiscent of real
cluster cores show evolution towards thermal collapse on a time scale which is
prolonged by a factor of ~2-10 compared with the zero-conduction cases. The
principal effect of the HBI is to re-orient field lines to be perpendicular to
the temperature gradient. Once the field has been wrapped up onto spherical
surfaces surrounding the core, the core is insulated from further conductive
heating (with the effective thermal conduction suppressed to less than 1/100th
of the Spitzer value) and proceeds to collapse. We speculate that, in real
clusters, the central AGN and possibly mergers play the role of "stirrers,"
periodically disrupting the azimuthal field structure and allowing thermal
conduction to sporadically heat the core.Comment: 16 pages, 3 tables, 17 figures, accepted to ApJ with minor revisions,
to appear in Volume 704, Oct 20, 2009 issu
Buoyancy Instabilities in a Weakly Collisional Intracluster Medium
The intracluster medium of galaxy clusters is a weakly collisional, high-beta
plasma in which the transport of heat and momentum occurs primarily along
magnetic-field lines. Anisotropic heat conduction allows convective
instabilities to be driven by temperature gradients of either sign, the
magnetothermal instability (MTI) in the outskirts of non-isothermal clusters
and the heat-flux buoyancy-driven instability (HBI) in their cooling cores. We
employ the Athena MHD code to investigate the nonlinear evolution of these
instabilities, self-consistently including the effects of anisotropic viscosity
(i.e. Braginskii pressure anisotropy), anisotropic conduction, and radiative
cooling. We highlight the importance of the microscale instabilities that
inevitably accompany and regulate the pressure anisotropies generated by the
HBI and MTI. We find that, in all but the innermost regions of cool-core
clusters, anisotropic viscosity significantly impairs the ability of the HBI to
reorient magnetic-field lines orthogonal to the temperature gradient. Thus,
while radio-mode feedback appears necessary in the central few tens of kpc,
conduction may be capable of offsetting radiative losses throughout most of a
cool core over a significant fraction of the Hubble time. Magnetically-aligned
cold filaments are then able to form by local thermal instability. Viscous
dissipation during the formation of a cold filament produces accompanying hot
filaments, which can be searched for in deep Chandra observations of nearby
cool-core clusters. In the case of the MTI, anisotropic viscosity maintains the
coherence of magnetic-field lines over larger distances than in the inviscid
case, providing a natural lower limit for the scale on which the field can
fluctuate freely. In the nonlinear state, the magnetic field exhibits a folded
structure in which the field-line curvature and field strength are
anti-correlated.Comment: 20 pages, 20 figures, submitted to ApJ; Abstract abridge
Tripotential Differentiation of Adherently Expandable Neural Stem (NS) Cells
BACKGROUND: A recent study has shown that pure neural stem cells can be derived from embryonic stem (ES) cells and primary brain tissue. In the presence of fibroblast growth factor 2 (FGF2) and epidermal growth factor (EGF), this population can be continuously expanded in adherent conditions. In analogy to continuously self-renewing ES cells, these cells were termed ‘NS’ cells (Conti et al., PLoS Biol 3: e283, 2005). While NS cells have been shown to readily generate neurons and astrocytes, their differentiation into oligodendrocytes has remained enigmatic, raising concerns as to whether they truly represent tripotential neural stem cells. METHODOLOGY/PRINCIPAL FINDINGS: Here we provide evidence that NS cells are indeed tripotent. Upon proliferation with FGF2, platelet-derived growth factor (PDGF) and forskolin, followed by differentiation in the presence of thyroid hormone (T3) and ascorbic acid NS cells efficiently generate oligodendrocytes (∼20%) alongside astrocytes (∼40%) and neurons (∼10%). Mature oligodendroglial differentiation was confirmed by transplantation data showing that NS cell-derived oligodendrocytes ensheath host axons in the brain of myelin-deficient rats. CONCLUSIONS/SIGNIFICANCE: In addition to delineating NS cells as a potential donor source for myelin repair, our data strongly support the view that these adherently expandable cells represent bona fide tripotential neural stem cells
The Relation Between the Surface Brightness and the Diameter for Galactic Supernova Remnants
In this work, we have constructed a relation between the surface brightness
() and diameter (D) of Galactic C- and S-type supernova remnants
(SNRs). In order to calibrate the -D dependence, we have carefully
examined some intrinsic (e.g. explosion energy) and extrinsic (e.g. density of
the ambient medium) properties of the remnants and, taking into account also
the distance values given in the literature, we have adopted distances for some
of the SNRs which have relatively more reliable distance values. These
calibrator SNRs are all C- and S-type SNRs, i.e. F-type SNRs (and S-type SNR
Cas A which has an exceptionally high surface brightness) are excluded. The
Sigma-D relation has 2 slopes with a turning point at D=36.5 pc: (at 1
GHz)=8.4 D
WmHzster (for
WmHzster and D36.5 pc) and (at 1
GHz)=2.7 10 D
WmHzster (for
WmHzster and D36.5 pc). We discussed the theoretical
basis for the -D dependence and particularly the reasons for the change
in slope of the relation were stated. Added to this, we have shown the
dependence between the radio luminosity and the diameter which seems to have a
slope close to zero up to about D=36.5 pc. We have also adopted distance and
diameter values for all of the observed Galactic SNRs by examining all the
available distance values presented in the literature together with the
distances found from our -D relation.Comment: 45 pages, 2 figures, accepted for publication in Astronomical and
Astrophysical Transaction
Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms
Objective: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. Method: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument. Results: The meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, n(effective) = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95% CI = 3.08%-8.18%). The contribution of additive genetic effects on internalizing symptoms appeared to be stable over age, with overlapping estimates of SNP heritability from early childhood to adolescence. Genetic correlations were observed with adult anxiety, depression, and the well-being spectrum (vertical bar r(g)vertical bar > 0.70), as well as with insomnia, loneliness, attention-deficit/hyperactivity disorder, autism, and childhood aggression (range vertical bar r(g)vertical bar = 0.42-0.60), whereas there were no robust associations with schizophrenia, bipolar disorder, obsessive-compulsive disorder, or anorexia nervosa. Conclusion: Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the way to future GWAS success.Peer reviewe
Highlights From the Annual Meeting of the American Epilepsy Society 2022
With more than 6000 attendees between in-person and virtual offerings, the American Epilepsy Society Meeting 2022 in Nashville, felt as busy as in prepandemic times. An ever-growing number of physicians, scientists, and allied health professionals gathered to learn a variety of topics about epilepsy. The program was carefully tailored to meet the needs of professionals with different interests and career stages. This article summarizes the different symposia presented at the meeting. Basic science lectures addressed the primary elements of seizure generation and pathophysiology of epilepsy in different disease states. Scientists congregated to learn about anti-seizure medications, mechanisms of action, and new tools to treat epilepsy including surgery and neurostimulation. Some symposia were also dedicated to discuss epilepsy comorbidities and practical issues regarding epilepsy care. An increasing number of patient advocates discussing their stories were intertwined within scientific activities. Many smaller group sessions targeted more specific topics to encourage member participation, including Special Interest Groups, Investigator, and Skills Workshops. Special lectures included the renown Hoyer and Lombroso, an ILAE/IBE joint session, a spotlight on the impact of Dobbs v. Jackson on reproductive health in epilepsy, and a joint session with the NAEC on coding and reimbursement policies. The hot topics symposium was focused on traumatic brain injury and post-traumatic epilepsy. A balanced collaboration with the industry allowed presentations of the latest pharmaceutical and engineering advances in satellite symposia
From Sea to Sea: Canada's Three Oceans of Biodiversity
Evaluating and understanding biodiversity in marine ecosystems are both necessary and challenging for conservation. This paper compiles and summarizes current knowledge of the diversity of marine taxa in Canada's three oceans while recognizing that this compilation is incomplete and will change in the future. That Canada has the longest coastline in the world and incorporates distinctly different biogeographic provinces and ecoregions (e.g., temperate through ice-covered areas) constrains this analysis. The taxonomic groups presented here include microbes, phytoplankton, macroalgae, zooplankton, benthic infauna, fishes, and marine mammals. The minimum number of species or taxa compiled here is 15,988 for the three Canadian oceans. However, this number clearly underestimates in several ways the total number of taxa present. First, there are significant gaps in the published literature. Second, the diversity of many habitats has not been compiled for all taxonomic groups (e.g., intertidal rocky shores, deep sea), and data compilations are based on short-term, directed research programs or longer-term monitoring activities with limited spatial resolution. Third, the biodiversity of large organisms is well known, but this is not true of smaller organisms. Finally, the greatest constraint on this summary is the willingness and capacity of those who collected the data to make it available to those interested in biodiversity meta-analyses. Confirmation of identities and intercomparison of studies are also constrained by the disturbing rate of decline in the number of taxonomists and systematists specializing on marine taxa in Canada. This decline is mostly the result of retirements of current specialists and to a lack of training and employment opportunities for new ones. Considering the difficulties encountered in compiling an overview of biogeographic data and the diversity of species or taxa in Canada's three oceans, this synthesis is intended to serve as a biodiversity baseline for a new program on marine biodiversity, the Canadian Healthy Ocean Network. A major effort needs to be undertaken to establish a complete baseline of Canadian marine biodiversity of all taxonomic groups, especially if we are to understand and conserve this part of Canada's natural heritage
- …